Disorders of the Adrenal Gland Practice Test 2026 - Free Adrenal Gland Disorders Practice Questions and Study Guide

Fludrocortisone acts as a mineralocorticoid, promoting sodium and water reabsorption and potassium excretion. When the dose is higher than needed, this mineralocorticoid effect can cause fluid retention, leading to weight gain, edema, and potential increases in blood pressure. Because weight gain reflects excess mineralocorticoid activity, it’s a key sign to report so the dose can be adjusted to avoid complications.

Fever or cough/shortness of breath point to infections or other conditions rather than a direct drug effect, and weight loss would suggest under-replacement with dehydration and electrolyte imbalance rather than over-replacement.